Gwen Buel, Ph.D.

Prior to joining L&A, Gwen worked as a Senior Scientist at a Cambridge-based biotech company where she developed a novel purification methodology for Anellovirus capsid proteins and optimized in vitro encapsidation methods with cssDNA payload.

Gwen conducted postdoctoral research at the National Cancer Institute (NIH), where she developed expertise in structural biology, protein biochemistry, and advanced analytical methods. She solved the solution NMR structure of Myosin VI in complex with Clathrin, and incorporated structure prediction tools (AlphaFold) to aid in the interpretation of NMR data for a weak interaction between E3 ligase E6AP and UBQLN1/2. Her postdoctoral work was recognized with the CCR Excellence in Postdoctoral Research Transition Award and the Sallie Rosen Kaplan Postdoctoral Fellowship for Women Scientists, and resulted in publications in Nature Communications, Nature Structural & Molecular Biology, and Structure.

Gwen earned her Ph.D. in Biological and Biomedical Sciences from Harvard University, where her research focused on amino acid regulation of mTORC1. Her graduate work was supported by an NIH F31 National Research Service Award (NRSA) Fellowship through the National Cancer Institute.

Gwen received her Bachelor of Science in Biochemistry, with a minor in Neurobiology, from the University of Vermont. There, she conducted undergraduate research on phosphoregulation of Collapsin Response Mediator Proteins resulting in a first-author publication in the Journal of Cellular Biochemistry.